The effect of space flight on the production of actinomycin D by Streptomyces plicatus

@article{Lam2002TheEO,
  title={The effect of space flight on the production of actinomycin D by Streptomyces plicatus},
  author={Kin Sing Lam and Donald R. Gustavson and D L Pirnik and Edward J Pack and Cecile A Bulanhagui and Steven W Mamber and Salvatore Forenza and Louis S. Stodieck and David M. Klaus},
  journal={Journal of Industrial Microbiology and Biotechnology},
  year={2002},
  volume={29},
  pages={299-302}
}
The effect of space flight on production of the antibiotic actinomycin D by Streptomyces plicatus WC56452 was examined onboard the US Space Shuttle mission STS-80. Paired space flight and ground control samples were similarly prepared using identical hardware, media, and inoculum. The cultures were grown in defined and complex media under dark, anaerobic, thermally controlled (20°C) conditions with samples fixed after 7 and 12 days in orbit, and viable residuals maintained through landing at 17… CONTINUE READING