The effect of somatostatin on release and insulinotropic action of gastric inhibitory polypeptide.

@article{Pederson1975TheEO,
  title={The effect of somatostatin on release and insulinotropic action of gastric inhibitory polypeptide.},
  author={Raymond A. Pederson and J R Dryburgh and John Canvin Brown},
  journal={Canadian journal of physiology and pharmacology},
  year={1975},
  volume={53 6},
  pages={1200-5}
}
Studies were carried out in conscious dogs in which the effect of intravenous somatostatin on immunoreactive gastric inhibitory polypeptide (IR-GIP) release was investigated. In addition, the inhibitory action of somatostatin on the insulin response to pure porcine GIP was assessed. Intravenous administration of somatostatin resulted in a delayed IR-GIP and immunoreactive insulin (IRI) response to oral glucose. Somatostatin also delayed the IR-GIP response to the ingestion of fat. In both types… CONTINUE READING
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