The effect of sodium molybdate on the cytoplasmic estrogen and progesterone receptors in human endometrial tissues.

@article{Shyamala1981TheEO,
  title={The effect of sodium molybdate on the cytoplasmic estrogen and progesterone receptors in human endometrial tissues.},
  author={Gopalan Shyamala and Alex S Ferenczy},
  journal={Diagnostic gynecology and obstetrics},
  year={1981},
  volume={3 4},
  pages={277-82}
}
We have investigated the effects of including 10 mM sodium molybdate in the buffers used for analysis of cytoplasmic estrogen and progesterone receptors of normal human proliferative endometrium and endometrial carcinoma. Sodium molybdate does not increase the steroid binding capacity of the receptors, but imparts stability to the steroid bound receptor; the steroid-bound receptors in molybdate treated cytosol sediment as distinct 8-9S moieties in sucrose gradients of low ionic strength in… CONTINUE READING