The effect of social stress on adrenal axis activity in horses: the importance of monitoring corticosteroid-binding globulin capacity.

@article{Alexander1998TheEO,
  title={The effect of social stress on adrenal axis activity in horses: the importance of monitoring corticosteroid-binding globulin capacity.},
  author={Susan L Alexander and Clifford H G Irvine},
  journal={The Journal of endocrinology},
  year={1998},
  volume={157 3},
  pages={425-32}
}
Plasma cortisol is largely bound to corticosteroid-binding globulin (CBG), which regulates its bioavailability by restricting exit from capillaries. Levels of CBG may be altered by several factors including stress and this can influence the amount of cortisol reaching cells. This study investigated the effect of social instability on plasma concentrations of CBG, total and free (not protein bound) cortisol in horses. Horses new to our research herd ('newcomers') were confined in a small yard… CONTINUE READING