The effect of smoking on MAOA promoter methylation in DNA prepared from lymphoblasts and whole blood.

@article{Philibert2010TheEO,
  title={The effect of smoking on MAOA promoter methylation in DNA prepared from lymphoblasts and whole blood.},
  author={Robert A Philibert and Steven R H Beach and Tracy D. Gunter and Gene H. Brody and Anup Madan and M. E. Gerrard},
  journal={American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics},
  year={2010},
  volume={153B 2},
  pages={619-628}
}
Prior work using lymphoblast DNA prepared from 192 subjects from the Iowa Adoption Studies (IAS) demonstrated that decreased MAOA promoter methylation was associated with lifetime symptom count for nicotine dependence (ND) and provided suggestive evidence that the amount of methylation is genotype dependent. In the current investigation, we replicate and extend these prior findings in three ways using another 289 IAS subjects and the same methodologies. First, we show that methylation is… CONTINUE READING