The effect of smoke inhalation on pulmonary surfactant.

  title={The effect of smoke inhalation on pulmonary surfactant.},
  author={Gary F. Nieman and William Roberts Clark and S D Wax and Stanley R. Webb},
  journal={Annals of surgery},
  volume={191 2},
This paper details efforts to define the primary pathophysiology of acute smoke inhalation without the variables of infection, burns, or fluid resuscitation. A standard dose of smoke (wood and kerosene) was delivered at 37 C to mongrel dogs. The parameters studied included blood gases, carboxyhemoglobin, pulmonary and systemic hemodynamics, respiratory mechanics, surface tension area curves as an indication of surfactant activity, and in vivo photomicroscopy. The FiO2 of the smoke was 17… CONTINUE READING