The effect of site of application on the transcutaneous absorption of 17-beta estradiol from a transdermal delivery system (Climara).

@article{Taggart2000TheEO,
  title={The effect of site of application on the transcutaneous absorption of 17-beta estradiol from a transdermal delivery system (Climara).},
  author={William R Taggart and K. R. Dandekar and Herman Ellman and Morris Notelovitz},
  journal={Menopause},
  year={2000},
  volume={7 5},
  pages={364-9}
}
OBJECTIVE The effect of site of application on 17-beta estradiol bioavailability was assessed in an open-label, randomized, crossover study of a once-weekly transdermal estradiol patch (Climara). DESIGN After placement of a transdermal patch delivering 0.1 mg/day of estradiol on either the buttocks or abdomen, serial plasma samples were obtained over 7 days and for the immediate 24 h after patch removal. Plasma estradiol concentrations were used to estimate pharmacokinetic parameters for the… CONTINUE READING