The effect of single-dose tramadol on oxycodone clearance.


We have noticed increased prescribing of tramadol by emergency physicians for breakthrough pain in patients chronically taking oxycodone. Both oxycodone and tramadol undergo oxidative metabolism by CYP2D6 and CYP3A4, suggesting the possibility that tramadol may compete with oxycodone for metabolism. A randomized controlled trial in 10 human volunteers was… (More)


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@article{Curry2007TheEO, title={The effect of single-dose tramadol on oxycodone clearance.}, author={Steven C. Curry and David Watts and Kenneth Darren Katz and Dale S. Bikin and Bonny L. Bukaveckas}, journal={The Journal of emergency medicine}, year={2007}, volume={33 4}, pages={407-11} }