The effect of side-chain functionality and hydrophobicity on the gene delivery capabilities of cationic helical polypeptides.

@article{Zhang2014TheEO,
  title={The effect of side-chain functionality and hydrophobicity on the gene delivery capabilities of cationic helical polypeptides.},
  author={Rujing Zhang and Nan Zheng and Ziyuan Song and Lichen Yin and Jianjun Cheng},
  journal={Biomaterials},
  year={2014},
  volume={35 10},
  pages={3443-54}
}
The rational design of effective and safe non-viral gene vectors is largely dependent on the understanding of the structure-property relationship. We herein report the design of a new series of cationic, α-helical polypeptides with different side charged groups (amine and guanidine) and hydrophobicity, and mechanistically unraveled the effect of polypeptide structure on the gene delivery capability. Guanidine-containing polypeptides displayed superior membrane activities to their amine… CONTINUE READING

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