The effect of short-term diets rich in fish, red meat, or white meat on thromboxane and prostacyclin synthesis in humans

@article{Mann1997TheEO,
  title={The effect of short-term diets rich in fish, red meat, or white meat on thromboxane and prostacyclin synthesis in humans},
  author={Neil J. Mann and Andrew J. Sinclair and Marita Pille and Leeann Johnson and Glenda E. Warrick and Elke Reder and Reinhard L Lorenz},
  journal={Lipids},
  year={1997},
  volume={32},
  pages={635-644}
}
Foods which increase tissue arachidonic acid levels have been proposed to increase thrombosis tendency, presumably through increased platelet aggregation. This study examined the effect of doubling the dietary arachidonic acid (20∶4n−6) using meat- or fish-based diets on the systemic production of prostacyclin (PGl2) and thromboxane (TXA2) in 29 healthy, nonsmoking adults. There were three, 3-wk low-fat dietary periods (<15% energy as fat) in which subjects consumed a vegetarian diet for 1 wk… 

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References

SHOWING 1-10 OF 62 REFERENCES
Long-term effects of dietary marine omega-3 fatty acids upon plasma and cellular lipids, platelet function, and eicosanoid formation in humans.
TLDR
Favorable changes induced by long-chain omega-3 fatty acids include a dose-related and sustained shift of the prostaglandin I/thromboxane A balance to a more antiaggregatory and vasodilatory state.
Long-term effects of dietary marine omega-3 fatty acids upon plasma and cellular lipids, platelet function, and eicosanoid formation in humans.
TLDR
Favorable changes induced by long-chain omega-3 fatty acids include a dose-related and sustained shift of the prostaglandin I/thromboxane A balance to a more antiaggregatory and vasodilatory state.
Short-term diets rich in arachidonic acid influence plasma phospholipid polyunsaturated fatty acid levels and prostacyclin and thromboxane production in humans.
TLDR
The results of these studies have shown that diets that contain both AA and n-3 LCP are associated with an increase in PGI2 production, without affecting TXA2 production.
The effects of very low fat diets enriched with fish or kangaroo meat on cold-induced vasoconstriction and platelet function.
Effects of dietary fat content, saturated fatty acids, and fish oil on eicosanoid production and hemostatic parameters in normal men.
TLDR
The studies showed that the effects of eicosapentaenoic and docosahexaenoic acids on platelet and vascular function and eICosanoid production are modulated by the content of saturated fatty acids in the diet.
The effects of low-fat diets rich in arachidonic acid on the composition of plasma fatty acids and bleeding time in Australian aborigines.
TLDR
A rise in bleeding time associated with an increased concentration of arachidonic acid and decreased concentration of linoleic acid in plasma lipids is demonstrated, and suggests that the mechanism by which diet modulates haemostatic function may be more complex than currently assumed.
Decreased systemic thromboxane A2 biosynthesis in normal human subjects fed a salmon-rich diet.
TLDR
Nine normal male subjects were fed a reference diet typical of that consumed in the United States and a diet containing approximately 450 g salmon (salmon-rich diet) and the percent energy contribution of protein, carbohydrate, and fat was identical for the two diets.
Prostaglandin I3 is formed in vivo in man after dietary eicosapentaenoic acid
TLDR
It is shown here that the major urinary metabolite of endogenous prostaglandin I3 is present in subjects that have ingested either cod liver oil or mackerel, and provides the first direct evidence for in vivo formation of prostaglandsin I2 in man.
The antihypertensive effects of fish oil. A controlled study of polyunsaturated fatty acid supplements in essential hypertension.
TLDR
The data indicate that high doses of fish oil can reduce blood pressure in men with essential hypertension, however, the clinical usefulness and safety ofFish oil in the treatment of hypertension will require further study.
In vivo indexes of platelet and vascular function during fish-oil administration in patients with atherosclerosis.
TLDR
These studies show that a high dose of eicosapentaenoate alters the pattern of synthesis of thromboxanes and prostacyclins, and whether other properties of fish oil might render it a more attractive antithrombotic therapy remains to be determined.
...
1
2
3
4
5
...