The effect of sex steroids on insulin binding by target tissues in the rat.

  title={The effect of sex steroids on insulin binding by target tissues in the rat.},
  author={Gustavo Ballejo and Tahia H. Saleem and F S Khan-dawood and John C. M. Tsibris and William N. Spellacy},
  volume={28 5},
Pubescence-related changes in hepatocyte insulin dynamics in female rats.
Insulin binding and receptor-mediated insulin processing were investigated in isolated hepatocytes from sexually maturing female rats and from age-matched animals that had undergone prepubertal
Adipocyte insulin receptor binding and lipogenesis at term in normal pregnancy
The findings indicate that lipogenesis in subcutaneous abdominal adipocytes from pregnant women is increased due to post‐receptor events and that adipocytes do not contribute to the insulin resistance in late pregnancy.
Role of Estrogens in Peripheral and Cerebral Glucose Utilization
This literature review provides substantial evidence that estradiol plays a modulatory role in both peripheral and cerebral glucose metabolism and that estrogen deprivation associated with the menopause may exert its various CNS effects by reducing glucose availability to brain cells.


Effects of Estrogen on Glucose Uptake by Rat Muscle 1
The data indicate that treatment with naturally occurring estrogens increases muscle sensitivity to insulin-stimulated glucose uptake, and suggest that the carbohydrate intolerance associated with the administration of oral contraceptives may be related to the use of synthetic rather than natural estrogens and/or progestins in such preparations.
Effects of Pregnancy and Sex Steroid Administration on Skeletal Muscle Metabolism in the Rat
To determine whether the insulin resistance, exaggerated fasting hypoglycemia, and hypoalaninemia of late human and rat gestation may reflect altered skeletal muscle metabolism, hindlimbs of
Relative effects of pregnancy, estradiol, and progesterone on plasma insulin and pancreatic islet insulin secretion.
Results indicate that estradiol and progesterone contribute to enhanced islet insulin secretion and plasma insulin responses to glucose administration during pregnancy, which can be related to hypertrophy of islets following chronic hormonal administration.
Estrogen receptor in rat pancreatic islets.
Effect of dexamethasone on insulin binding, glucose transport, and glucose oxidation of isolated rat adipocytes.
  • J. Olefsky
  • Biology, Medicine
    The Journal of clinical investigation
  • 1975
All of the in vitro effects of dexamethasone on glucose oxidation are due to direct inhibition of the glucose transport system, according to a direct glucocorticoid effect on the glucose Transport system.
Cytoplasmic 17β-[3H]Estradiol Binding in Rat Adipose Tissues*
High affinity, estrogen-specific macromolecular binding of 17β-[3H]estradiol in the cytoplasmic fraction of adipose tissues from ovariectomized rats is found and binding is seen in all adipose tissue studied, including abdominal, sc, and brown fat.
Changes in insulin receptors during oral contraception.
The present data appear to confirm that sex steroids affect the insulin receptor and lend further support to the concept that caution must be used in clinical studies of insulin receptors when women are included, and suggest that insulin receptors may play a role in the glucose intolerance and insulin insensitivity which have been described in pill users.
Progestin Enhancement of the Plasma Insulin Response to Glucose in Rhesus Monkeys
  • P. Beck
  • Medicine, Biology
  • 1969
The data suggest that pure progesterone, like human placental lactogen, may be a diabetogenic factor in pregnancy and indicate that some, but not all, of the synthetic progestins may contribute to the changes in glucose and insulin metabolism observed in women taking oral contraceptive agents.