The effect of setup uncertainty on normal tissue sparing with IMRT for head-and-neck cancer.

@article{Manning2001TheEO,
  title={The effect of setup uncertainty on normal tissue sparing with IMRT for head-and-neck cancer.},
  author={Matthew A Manning and Q Jackie Wu and Robert M Cardinale and Radhe Mohan and Andrew Lauve and Brian D. Kavanagh and Monica M. Morris and Rupert K A Schmidt-Ullrich},
  journal={International journal of radiation oncology, biology, physics},
  year={2001},
  volume={51 5},
  pages={1400-9}
}
PURPOSE Intensity-modulated radiotherapy (IMRT) is being evaluated in the management of head-and-neck cancers at several institutions, and a Radiation Therapy Oncology Group study of its utility in parotid sparing is under development. There is an inherent risk that the sharper dose gradients generated by IMRT amplify the potentially detrimental impact of setup uncertainty. The International Commission on Radiation Units and Measurements Report 62 (ICRU-62) defined planning organ-at-risk volume… CONTINUE READING

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Application of an independent dose calculation software for estimating the impact of inter-fractional setup shifts in Helical Tomotherapy treatments.

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