The effect of select nutrients on serum high-density lipoprotein cholesterol and apolipoprotein A-I levels.

@article{Mooradian2006TheEO,
  title={The effect of select nutrients on serum high-density lipoprotein cholesterol and apolipoprotein A-I levels.},
  author={Arshag D. Mooradian and Michael J Haas and Norman C. W. Wong},
  journal={Endocrine reviews},
  year={2006},
  volume={27 1},
  pages={
          2-16
        }
}
One of the factors contributing to the increased risk of developing premature atherosclerosis is low plasma concentrations of high-density lipoprotein (HDL) cholesterol (HDLc). Multiple potential mechanisms account for the cardioprotective effects of HDL and its main protein apolipoprotein A-I (apo A-I). The low plasma concentrations of HDL could be the result of increased fractional clearance and reduced expression of apo A-I. To this end, nutrients play an important role in modulating the… 
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References

SHOWING 1-10 OF 161 REFERENCES
Effects of nicotinic acid therapy on plasma high density lipoprotein subfraction distribution and composition and on apolipoprotein A metabolism.
TLDR
The data suggest that the effects of nicotinic acid on the HDL subfraction distribution may be mediated via (a) net transfer of ApoA-I from HDL(3) to HDL(2) and (b) a reduction in ApOA-II synthesis.
High-density lipoprotein metabolism: Molecular targets for new therapies for atherosclerosis
TLDR
The next decade will witness the transition from preclinical studies to clinical trials of a variety of new therapies targeted toward HDL metabolism and atherosclerosis.
Reduction of high density lipoprotein cholesterol and apoliproprotein A-I concentrations by a lipid-lowering diet.
Dietary cholic acid lowers plasma levels of mouse and human apolipoprotein A-I primarily via a transcriptional mechanism.
TLDR
It is suggested that dietary cholate regulates plasma levels of apoA-I primarily by a transcriptional mechanism via a putative bile acid response element involving a negative regulator of api-I, and partly by an unidentified post-transcriptional mechanism.
Exploiting the Vascular Protective Effects of High-Density Lipoprotein and Its Apolipoproteins: An Idea Whose Time for Testing Is Coming, Part I
TLDR
The structure/function of HDL is reviewed and means of enhancing the levels and/or function of HDL and its apolipoproteins for vascular protection are explored.
Differential effects of dietary fat on the tissue-specific expression of the apolipoprotein A-I gene: relationship to plasma concentration of high density lipoproteins.
TLDR
Data indicate that dietary polyunsaturated fat can selectively alter the expression of the apoA-I gene in a tissue-specific manner.
Dietary Fat Elevates Hepatic ApoA-I Production by Increasing the Fraction of Apolipoprotein A-I mRNA in the Translating Pool (*)
TLDR
The reported elevation of HDL-C by a HF/HC diet is attributable, in part, to an increase in the hepatic production of hapoA-1, and the hepatocellular processes associated with this induction are defined, to suggest a post-transcriptional mechanism that does not involve mRNA stability.
Diabetic Dyslipidemia: Basic Mechanisms Underlying the Common Hypertriglyceridemia and Low HDL Cholesterol Levels
TLDR
Increased free fatty acid transport in plasma, a common abnormality in insulin-resistant states, may be the underlying driving force for the two common lipid abnormalities seen in diabetes.
High-density lipoproteins and atherosclerosis.
  • D. Rader
  • Biology
    The American journal of cardiology
  • 2002
Dietary fat saturation affects apolipoprotein AII levels and HDL composition in postmenopausal women.
TLDR
A palmolein diet increased TC and HDL cholesterol compared with oleic acid sunflower oil diet; however, the increase in Apo AII but not in Apolipoprotein AII suggests the impairment of reverse cholesterol transport and potentially an increase in CHD risk.
...
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