The effect of sedimentation and diffusion on cellular uptake of gold nanoparticles.

  title={The effect of sedimentation and diffusion on cellular uptake of gold nanoparticles.},
  author={Eun Chul Cho and Qiang Zhang and Younan Xia},
  journal={Nature nanotechnology},
  volume={6 6},
In vitro experiments typically measure the uptake of nanoparticles by exposing cells at the bottom of a culture plate to a suspension of nanoparticles, and it is generally assumed that this suspension is well-dispersed. However, nanoparticles can sediment, which means that the concentration of nanoparticles on the cell surface may be higher than the initial bulk concentration, and this could lead to increased uptake by cells. Here, we use upright and inverted cell culture configurations to show… CONTINUE READING
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