The effect of season on cytokine expression in multiple sclerosis and healthy subjects.

@article{Stewart2007TheEO,
  title={The effect of season on cytokine expression in multiple sclerosis and healthy subjects.},
  author={Niall Stewart and Bruce F. Taylor and Anne-Louise Ponsonby and Fotini Pittas and Ingrid A. F. van der Mei and G. Woods and H. M. J. Walters},
  journal={Journal of neuroimmunology},
  year={2007},
  volume={188 1-2},
  pages={181-6}
}
We measured the levels of IFNgamma, TNFalpha, Il-4 and Il-10 produced by mitogen-stimulated peripheral blood mononuclear cells (PBMC) from healthy people, and those with the relapse/remitting form of multiple sclerosis. Blood was taken in summer and winter. Healthy people had a summer excess of Il-4, Il-10 and TNFalpha, and a winter excess of IFNgamma. Untreated MS cases had a summer excess of Il-10, whereas those treated with Interferon-beta had lower levels of all cytokines, and displayed no… CONTINUE READING