The effect of salvianolic acid B combined with laminar shear stress on TNF-alpha-stimulated adhesion molecule expression in human aortic endothelial cells.

@article{Xie2010TheEO,
  title={The effect of salvianolic acid B combined with laminar shear stress on TNF-alpha-stimulated adhesion molecule expression in human aortic endothelial cells.},
  author={Li Xia Xie and Siva Sundara Kumar Durairajan and Jia Hong Lu and Chen Li Liu and Wan Fung Kum and Yan Wang and Irene Koo and Wei Wu and Dong Han and Fulong Lao and Jian-Dong Huang and Min Li},
  journal={Clinical hemorheology and microcirculation},
  year={2010},
  volume={44 4},
  pages={
          245-58
        }
}
The study was conducted to investigate the effect of Salvianolic acid B (Sal B) on TNF-alpha-stimulated adhesion molecule expression i.e. vascular adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1) and E-selectin in human aortic endothelial cells (HAECs) under laminar shear stress (LSS) condition. Exposure of HAECs to LSS (12 dynes/cm(2) for 6 h decreased the TNF-alpha-induced protein expression of adhesion molecules i.e. VCAM-1, ICAM-1 and E-selectin. Pre-treatment of… CONTINUE READING

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