The effect of saluretics and spironolactone on aldosterone production and electrolyte excretion in man

  • H. C. Erbler
  • Published 1974 in Naunyn-Schmiedeberg's Archives of Pharmacology

Abstract

Healthy volunteers received orally the saluretics furosemide (40 mg/day) and thiabutazide (10 mg/day) over a 5-day period, and the aldosterone antagonist spironolactone (5 mg and 10 mg/kg per day) over 7-and 3-day periods, respectively. On the first day of treatment both saluretics induced a marked increase in sodium and water excretion, but only a moderate… (More)
DOI: 10.1007/BF00501608

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