The effect of saffron on weight and lipid profile: A systematic review, meta‐analysis, and dose–response of randomized clinical trials

@article{Rahmani2019TheEO,
  title={The effect of saffron on weight and lipid profile: A systematic review, meta‐analysis, and dose–response of randomized clinical trials},
  author={Jamal Rahmani and Nicla Manzari and Jacqueline Y. Thompson and Cain C. T. Clark and Gemma Villanueva and Hamed Kord Varkaneh and Parvin Mirmiran},
  journal={Phytotherapy Research},
  year={2019},
  volume={33},
  pages={2244 - 2255}
}
Plant derivatives such as carotenoids and phytosterols enrich foods have been shown to reduce plasma triglyceride (TG), low‐density lipoprotein (LDL) cholesterol, and cholesterol concentrations. The aim of this systematic review and meta‐analyses study was to investigate the effects of saffron on lipid profiles, reported in randomized controlled trials (RCTs). We performed a systematic electronic search in PubMed/MEDLINE, Cochrane, and SCOPUS to identify RCTs and screening of relevant articles… 
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14 Citations
Background Citations
3
Results Citations
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14 Citations

Citation Type

Citation Type

The Effect of Saffron Consumption on Liver Function: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials
TLDR
Saffron supplementation could not improve liver function tests including AST, ALT, and ALP among the adult population, and further clinical trials with larger sample size, longer duration, and higher doses of saffron should be conducted exclusively among patients with liver dysfunction.
Effect of saffron supplementation on liver enzymes: A systematic review and meta-analysis of randomized controlled trials.
Effect of saffron supplementation on oxidative stress parameters: A systematic review and meta‐analysis of randomized placebo‐controlled trials
TLDR
Saffron intake was shown to significantly impact MDA and TAC, indicating its beneficial properties in improving OS in unhealthy patients, however, additional RCTs are required to evaluate the effect on other OS parameters.
Effects of saffron (Crocus sativus L.) supplementation on inflammatory biomarkers: A systematic review and meta‐analysis
TLDR
The overall results indicated that saffron supplementation did not affect inflammatory cytokines and further high‐quality studies are needed to firmly establish the clinical efficacy of supplemental saffrons on inflammatory biomarkers.
Metabolic impact of saffron and crocin: an updated systematic and meta-analysis of randomised clinical trials.
TLDR
It is suggested that saffron and crocin may modulate the serum lipid profile in patient with metabolic disorders.
The effect of herbs and spices on risk factors for cardiometabolic diseases: a review of human clinical trials.
TLDR
To inform evidence-based guidelines for intake of herbs and spices for general health and cardiometabolic disease risk reduction, rigorously conducted randomized controlled trials are needed, particularly trials examining herb and spice doses that can be incorporated into healthy dietary patterns.
Effects of crocin supplementation on inflammatory markers, lipid profiles, insulin and cardioprotective indices in women with PCOS: A randomized, double-blind, placebo-controlled trial.
TLDR
Crin supplementation could be considered in the therapeutic targets of women with PCOS because it significantly increased the mean high-density lipoprotein cholesterol postintervention compared to the placebo group, while exerting a suppressive effect on the increase in mean low-density cholesterol, triglycerides, and cholesterol levels.
Effect of Daily Intake of a Saffron Infusion on Blood Cholesterol Levels
TLDR
The intake of an infusion of 50 mg of “Azafrán de La Mancha” for 96 days had a lipid-lowering effect in patients with MS, and a significant decrease in total blood cholesterol levels was observed.
The therapeutic potential of Crocus sativus Linn.: A comprehensive narrative review of clinical trials.
TLDR
The present results can provide important insights into the potential of saffron in preventing and treating different disorders, with a special focus on the underlying cellular and molecular mechanisms.
Activity of Antioxidants from Crocus sativus L. Petals: Potential Preventive Effects towards Cardiovascular System
TLDR
The results indicate that SPE, a by-product of saffron cultivation, may represent a good source of phytochemicals with a potential application in the prevention of cardiovascular diseases.
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References

SHOWING 1-10 OF 56 REFERENCES
Effect of crocin, a carotenoid from saffron, on plasma cholesteryl ester transfer protein and lipid profile in subjects with metabolic syndrome: A double blind randomized clinical trial
TLDR
Although crocin supplements increased the serum cholesteryl ester transfer protein in patients with metabolic syndrome, this change was not significant between treatment and placebo groups.
The Efficacy of Crocin of Saffron (Crocus sativus L.) on the Components of Metabolic Syndrome: A Randomized Controlled Clinical Trial
TLDR
The present study indicated that the dose of about 100 mg crocin of saffron was well tolerated and has no complication for 6 weeks of oral administration, however, the dosage used in this study had no effect on metabolic syndrome.
Saffron; An updated review on biological properties with special focus on cardiovascular effects.
Study the effects of saffron on depression and lipid profiles: A double blind comparative study.
Saffron and crocin improved appetite, dietary intakes and body composition in patients with coronary artery disease
TLDR
The results of present study regarding anti-obesity feature of SAE and crocin in patients with CAD was promising, however the SAE was better in appetite suppressing, dietary intake and central obesity reduction.
Anti-Dyslipidemic Properties of Saffron: Reduction in the Associated Risks of Atherosclerosis and Insulin Resistance
TLDR
It is demonstrated that saffron extracts, particularly the mixture of extracts from stigma and petal, ameliorated dyslipidemia in obese rats, leading to decreased atherosclerosis and insulin resistance.
Effect of crocin extracted from saffron on pro-oxidant–anti-oxidant balance in subjects with metabolic syndrome: A randomized, placebo-controlled clinical trial
The effect of saffron (Crocus sativus L.) hydroalcoholic extract on metabolic control in type 2 diabetes mellitus: A triple-blinded randomized clinical trial
TLDR
Saffron hydroalcoholic extract may improve blood glucose control by reducing FBS in T2D patients, however, saffron extract has no significant effect on other aspects of diabetic control in diabetic patients.
Effect of Saffron ( Crocus sativus L.) as an Add-On Therapy to Sertraline in Mild to Moderate Generalized Anxiety Disorder: A Double Blind Randomized Controlled Trial
TLDR
Saffron as a sertraline add-on therapy may attenuate GAD symptoms, however, more randomized clinical trials with a larger sample size and longer duration of follow-up are needed to confirm this effect.
Anti-Inflammatory Effect of Crocus sativus on Serum Cytokine Levels in Subjects with Metabolic Syndrome: A Randomized, Double-Blind, Placebo- Controlled Trial.
TLDR
The findings provide a novel insight into the therapeutic effects of this therapy in MetS patients via perturbation of serum cytokines and reducing the levels of triglyceride and LDL/TC, but further studies are required in larger populations.
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