The effect of rhBMP-2 on canine osteoblasts seeded onto 3D bioactive polycaprolactone scaffolds.

@article{Rai2004TheEO,
  title={The effect of rhBMP-2 on canine osteoblasts seeded onto 3D bioactive polycaprolactone scaffolds.},
  author={Bina Rai and Swee Hin Teoh and Kee Hai Ho and Dietmar Werner Hutmacher and Tong Cao and Feiyue Chen and Kamal Bin Yacob},
  journal={Biomaterials},
  year={2004},
  volume={25 24},
  pages={5499-506}
}
Our strategy entails investigating the influence of varied concentrations (0, 10, 100 and 1000ng/ml) of human recombinant bone morphogenetic protein-2 (rhBMP-2) on the osteogenic expression of canine osteoblasts, seeded onto poly-caprolactone 20% tricalcium phosphate (PCL-TCP) scaffolds in vitro. Biochemical assay revealed that groups with rhBMP-2 displayed an initial burst in cell growth that was not dose-dependent. However, after 13 days, cell growth declined to a value similar to control… CONTINUE READING

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