The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935.

@article{Mccay1989TheEO,
  title={The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935.},
  author={Clive M. Mccay and Mary F. Crowell and Leonard Amby Maynard},
  journal={Nutrition},
  year={1989},
  volume={5 3},
  pages={
          155-71; discussion 172
        }
}
mary in the nature of a progress report dealing with a study employing rats to determine the effect of retarding growth upon the total length of life. The present summary represents a complete, final report of this experiment employing white rats and covering a period of nearly 4 years. The object of this study was to determine the effect of retarding growth upon the total length of life and to measure the effects of retarded growth upon the ultimate size of the animal's body. In the present… Expand
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Dietary restriction offers gerontologists a unique system for studying the aging process because dietary restriction increases the maximum survival of rodents and alters most physiological and pathological processes that change with increasing age. Expand
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In the years following the seminal 1935 paper, it was shown that the nutritional factor underlying the life extension is the reduction in energy intake; thus the term caloric restriction (CR) has been widely used when referring to this phenomenon. Expand
Honoring Clive McCay and 75 years of calorie restriction research.
This volume and issue of The Journal of Nutrition marks the 75th anniversary of the publication by McCay, Crowell, and Maynard entitled “The Effect of Retarded Growth upon the Length of Life Span and… Expand
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  • E. Masoro
  • Medicine
  • Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1990
TLDR
It appears that most of the actions of food restriction are due to its ability to slow the primary aging processes, and this action to relate to the restriction of calories rather than specific nutrients (e.g., protein or fat or minerals). Expand
McCay's hypothesis: undernutrition and longevity.
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  • Medicine
  • The Proceedings of the Nutrition Society
  • 1995
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The hypothesis that retardation of growth is the reason for the life extension is not valid and the life-extending action of DR is clearly a robust and reproducible phenomenon. Expand
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TLDR
Examination of body weight and longevity data from a study involving over 60,000 mice and rats, conducted by a National Institute on Aging-sponsored project, suggests that CR-related increase in life span of specific genotypes is directly related to the gain in body weight under the AL feeding regimen. Expand
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The effect of caloric restriction, which appears to be the important manipulation for extending life span and delaying the appearance of many age-related pathologies, is robust, being observed in spite of a wide range of experimental approaches, composition of the diet and intensity of calorie restriction. Expand
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The studies reported by McCay et al. (1935) that dietary restriction (DR) initiated in early youth of rats extends both average and maximum life spans have been extended by numerous investigators… Expand
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