The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935.

  title={The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935.},
  author={Clive M. Mccay and Mary F. Crowell and Leonard Amby Maynard},
  volume={5 3},
          155-71; discussion 172
mary in the nature of a progress report dealing with a study employing rats to determine the effect of retarding growth upon the total length of life. The present summary represents a complete, final report of this experiment employing white rats and covering a period of nearly 4 years. The object of this study was to determine the effect of retarding growth upon the total length of life and to measure the effects of retarded growth upon the ultimate size of the animal's body. In the present… 

Figures and Tables from this paper

Thoughts on the evolutionary basis of dietary restriction

Dietary restriction offers gerontologists a unique system for studying the aging process because dietary restriction increases the maximum survival of rodents and alters most physiological and pathological processes that change with increasing age.

History of Caloric Restriction, Aging and Longevity

In the years following the seminal 1935 paper, it was shown that the nutritional factor underlying the life extension is the reduction in energy intake; thus the term caloric restriction (CR) has been widely used when referring to this phenomenon.

Honoring Clive McCay and 75 years of calorie restriction research.

This volume and issue of The Journal of Nutrition marks the 75th anniversary of the publication by McCay, Crowell, and Maynard entitled “The Effect of Retarded Growth upon the Length of Life Span and

Assessment of Nutritional Components in Prolongation of Life and Health by Diet

  • E. Masoro
  • Medicine
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1990
It appears that most of the actions of food restriction are due to its ability to slow the primary aging processes, and this action to relate to the restriction of calories rather than specific nutrients (e.g., protein or fat or minerals).

McCay's hypothesis: undernutrition and longevity

  • E. Masoro
  • Biology
    Proceedings of the Nutrition Society
  • 1995
The hypothesis that retardation of growth is the reason for the life extension is not valid and the life-extending action of DR is clearly a robust and reproducible phenomenon.

Dietary Restriction in Aging

The effect of caloric restriction, which appears to be the important manipulation for extending life span and delaying the appearance of many age-related pathologies, is robust, being observed in spite of a wide range of experimental approaches, composition of the diet and intensity of calorie restriction.

Models for Investigating How Dietary Restriction Retards Aging: The Adaptation Hypothesis

From 1935 until the early 1970s essentially all studies of DR concerned its effect(s) on survival and/or diseases, especially tumors, and from about 1972 on, a major preoccupation of investigators has been with documenting the physiologic and “biomarker” effects.

The effects of different levels of dietary restriction on aging and survival in the Sprague-Dawley rat: Implications for chronic studies

Although the 104-week survival rate for these SD, non-obese AL rats exceeds the FDA’s “Redbook” survival guideline (> 50%) for chronic bioassays, the use of DR is advocated because it reduces individual variability in body weight.

The Quartercentenary Lecture

About 60 years ago McCay et al. (1935,1939) showed that limiting the food intake of rats increased their life span and reduced symptoms of degenerative disease. Almost 30 years earlier Moreschi



Death-Rates in Great Britain and Sweden: Expression of Specific Mortality Rates as Products of Two Factors, and some Consequences thereof

1. The specific mortality rates for males, females and the total population for England and Wales, for Scotland and for Sweden, have been fitted to a formula ƒ (t, θ) = α. (t—θ) βθ where ƒ (t, θ) is

Prolonging the Life Span

Rate of Growth and Length of Life.

  • H. ShermanH. L. Campbell
  • Medicine, Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1935

Prolonging the life span. Sci. Monthly

  • Prolonging the life span. Sci. Monthly
  • 1934