The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935.

@article{Mccay1989TheEO,
  title={The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935.},
  author={Clive M. Mccay and Mary F. Crowell and Leonard Amby Maynard},
  journal={Nutrition},
  year={1989},
  volume={5 3},
  pages={
          155-71; discussion 172
        }
}
mary in the nature of a progress report dealing with a study employing rats to determine the effect of retarding growth upon the total length of life. The present summary represents a complete, final report of this experiment employing white rats and covering a period of nearly 4 years. The object of this study was to determine the effect of retarding growth upon the total length of life and to measure the effects of retarded growth upon the ultimate size of the animal's body. In the present… 
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References

SHOWING 1-10 OF 14 REFERENCES

THE RESUMPTION OF GROWTH AFTER LONG CONTINUED FAILURE TO GROW

Death-Rates in Great Britain and Sweden: Expression of Specific Mortality Rates as Products of Two Factors, and some Consequences thereof

1. The specific mortality rates for males, females and the total population for England and Wales, for Scotland and for Sweden, have been fitted to a formula ƒ (t, θ) = α. (t—θ) βθ where ƒ (t, θ) is…

Prolonging the Life Span

Weights of various organs in the adult rat after inanition with or without the dietary accessories.

The Interrelations of Various Probability Tables and a Modification of Student's Probability Table for the Argument “t”1

Cellulose in the diet of rats and mice.

Growth Rates of Brook Trout Reared upon Purified Rations, upon Dry Skim Milk Diets, and upon Feed Combinations of Cereal Grains

EXPERIMENTAL STUDIES ON GROWTH XV. ON THE GROWTH OF RELATIVELY LONG LIVED COMPARED WITH THAT OF RELATIVELY SHORT LIVED ANIMALS

Rate of Growth and Length of Life.

  • H. ShermanH. L. Campbell
  • Medicine, Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1935

Prolonging the life span. Sci. Monthly

  • Prolonging the life span. Sci. Monthly
  • 1934