The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935.

  title={The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935.},
  author={Clive M. Mccay and Mary F. Crowell and Leonard Amby Maynard},
  volume={5 3},
          155-71; discussion 172
mary in the nature of a progress report dealing with a study employing rats to determine the effect of retarding growth upon the total length of life. The present summary represents a complete, final report of this experiment employing white rats and covering a period of nearly 4 years. The object of this study was to determine the effect of retarding growth upon the total length of life and to measure the effects of retarded growth upon the ultimate size of the animal's body. In the present… Expand
Thoughts on the evolutionary basis of dietary restriction
Dietary restriction offers gerontologists a unique system for studying the aging process because dietary restriction increases the maximum survival of rodents and alters most physiological and pathological processes that change with increasing age. Expand
History of Caloric Restriction, Aging and Longevity
In the years following the seminal 1935 paper, it was shown that the nutritional factor underlying the life extension is the reduction in energy intake; thus the term caloric restriction (CR) has been widely used when referring to this phenomenon. Expand
Honoring Clive McCay and 75 years of calorie restriction research.
This volume and issue of The Journal of Nutrition marks the 75th anniversary of the publication by McCay, Crowell, and Maynard entitled “The Effect of Retarded Growth upon the Length of Life Span andExpand
Assessment of Nutritional Components in Prolongation of Life and Health by Diet
  • E. Masoro
  • Medicine
  • Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1990
It appears that most of the actions of food restriction are due to its ability to slow the primary aging processes, and this action to relate to the restriction of calories rather than specific nutrients (e.g., protein or fat or minerals). Expand
McCay's hypothesis: undernutrition and longevity.
  • E. Masoro
  • Medicine
  • The Proceedings of the Nutrition Society
  • 1995
The hypothesis that retardation of growth is the reason for the life extension is not valid and the life-extending action of DR is clearly a robust and reproducible phenomenon. Expand
Caloric restriction and the aging process: a critique.
Examination of body weight and longevity data from a study involving over 60,000 mice and rats, conducted by a National Institute on Aging-sponsored project, suggests that CR-related increase in life span of specific genotypes is directly related to the gain in body weight under the AL feeding regimen. Expand
Dietary Restriction in Aging
The effect of caloric restriction, which appears to be the important manipulation for extending life span and delaying the appearance of many age-related pathologies, is robust, being observed in spite of a wide range of experimental approaches, composition of the diet and intensity of calorie restriction. Expand
Models for Investigating How Dietary Restriction Retards Aging: The Adaptation Hypothesis
The studies reported by McCay et al. (1935) that dietary restriction (DR) initiated in early youth of rats extends both average and maximum life spans have been extended by numerous investigatorsExpand
The effects of different levels of dietary restriction on aging and survival in the Sprague-Dawley rat: Implications for chronic studies
Although the 104-week survival rate for these SD, non-obese AL rats exceeds the FDA’s “Redbook” survival guideline (> 50%) for chronic bioassays, the use of DR is advocated because it reduces individual variability in body weight. Expand
History of the Study of Calorie Restriction in Nonhuman Primates Conducted by the National Institute on Aging: The First Decade
Beginning in 1987 a long-term study was initiated by the National Institute on Aging to evaluate the effects on health, disease, and aging of a regimen of calorie restriction (CR) in nonhumanExpand


Rate of Growth and Length of Life.
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  • 1935
Prolonging the Life Span
Prolonging the life span. Sci. Monthly
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