The effect of residue 1106 on the thioester-mediated covalent binding reaction of human complement protein C4 and the monomeric rat alpha-macroglobulin alpha 1 I3.

Abstract

The histidine at position 1106 of the C4B isotype of human complement is involved in catalyzing the covalent binding of the thioester to glycerol and water. By replacing the histidine with other residues, it was found that tyrosine is also capable of mediating the reaction. We propose that they act as nucleophiles by first attacking the thioester, upon… (More)

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@article{Ren1995TheEO, title={The effect of residue 1106 on the thioester-mediated covalent binding reaction of human complement protein C4 and the monomeric rat alpha-macroglobulin alpha 1 I3.}, author={Xintong Ren and Alister W. Dodds and Jan J Enghild and C-C Chu and S. K. Law}, journal={FEBS letters}, year={1995}, volume={368 1}, pages={87-91} }