The effect of reperfusion on neuroprotection using an inhibitor of poly(ADP-ribose) polymerase.

@article{Takahashi1999TheEO,
  title={The effect of reperfusion on neuroprotection using an inhibitor of poly(ADP-ribose) polymerase.},
  author={Kumiko Takahashi and Joel H. Greenberg},
  journal={Neuroreport},
  year={1999},
  volume={10 10},
  pages={2017-22}
}
The activation of poly(ADP-ribose) polymerase (PARP) by free radical-damaged DNA plays a pivotal role in mediating ischemia-reperfusion injury. The purpose of the present study was to examine the neuroprotective effects of a PARP inhibitor, 3-aminobenzamide (3-ABA), which was administered either prior to or following reperfusion, to determine the importance of PARP inhibition prior to reperfusion. 3-ABA was injected i.p. either 15 min before or 15 min following reperfusion in a transient focal… CONTINUE READING

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