The effect of repeat transurethral resection on recurrence and progression rates in patients with T1 tumors of the bladder who received intravesical mitomycin: a prospective, randomized clinical trial.

  title={The effect of repeat transurethral resection on recurrence and progression rates in patients with T1 tumors of the bladder who received intravesical mitomycin: a prospective, randomized clinical trial.},
  author={Rauf Taner Divrik and Umit Can Yildirim and Ferruh Zorlu and Haluk Ozen},
  journal={The Journal of urology},
  volume={175 5},
PURPOSE We compared the outcomes of repeat transurethral resection plus intravesical mitomycin C with initial transurethral resection of bladder plus intravesical MMC in patients with newly diagnosed pT1 transitional cell carcinoma of the bladder in terms of recurrence, progression and overall survival. MATERIALS AND METHODS Of 148 newly diagnosed patients with T1 bladder cancer 142 were prospectively randomized in 2 groups between January 2001 and January 2005. A total of 74 patients… Expand
Impact of routine second transurethral resection on the long-term outcome of patients with newly diagnosed pT1 urothelial carcinoma with respect to recurrence, progression rate, and disease-specific survival: a prospective randomised clinical trial.
It is clearly shown that second TUR, which is performed only after complete first TUREthral resection of bladder tumours, has significantly decreased the recurrence and progression rates in patients with newly diagnosed T1 disease compared to patients with T2 disease but with no first TUR. Expand
Can a second resection be avoided after initial thulium laser endoscopic en bloc resection for non-muscle invasive bladder cancer? A retrospective single-center study of 251 patients
Evaluated transurethral thulium laser en bloc resection of the bladder tumor in patients with non-muscle invasive bladder cancer found this technique may decrease the number of second TURs. Expand
The value of extensive transurethral resection in the diagnosis and treatment of nonmuscle invasive bladder cancer with respect to recurrence at the first follow-up cystoscopy
Routine extensive TUR is helpful for the pathological diagnosis and the post-TUR treatment of NMIBC and can significantly reduce the RR-FFC of N MIBC, especially in patients with T1 stage or high-grade disease. Expand
A Second-Look at the Repeat Resections of Bladder Tumors
Evaluated patients with non-muscle invasive bladder cancer who underwent a second TURBT found no significant difference in overall survival, progression, or recurrence rate, and there was a small rate of upstaging to pT2 disease on repeat TUR BT. Expand
Can immediate second resection be an alternative to standardized second transurethral resection of bladder tumors?
The initial results supported the assertion that immediate second resection can be an alternative to standard second TURBT, and demonstrated that residual tumors may remain after initial TURB, either in the tumor bed or in a different location within the bladder. Expand
Second Transurethral Resection of Bladder Tumor: Is it Necessary in All T1 and/or High-Grade Tumors?
It is shown that second TURBT in a subset of patients with single, small T1 and/or high-grade tumor who underwent complete initial resection might be of limited value. Expand
The prognostic value of routine second transurethral resection in patients with newly diagnosed stage pT1 non-muscle-invasive bladder cancer: results from randomized 10-year extension trial
Findings indicate the prognostic value of second TUR in stage pT1 NMIBC patients, not only for RFS and PFS advantages but also for the long-term OS advantage. Expand
Results of repeated transurethral resection for a second opinion in patients referred for nonmuscle invasive bladder cancer: the referral cancer center experience and review of the literature.
A second TUR is recommended to reduce the chance of residual tumor and staging error because of nonstandardized TUR in the patients referred to an academic or referral center for a second opinion, irrespective of previous tumor stage. Expand
Results of second transurethral resection for high-grade T1 bladder cancer
Second TUR allows more accurate staging and pT0 cases in second TUR have a better outcome, indicating a possible therapeutic benefit of the procedure, and was a significant factor in overall survival. Expand
The impact of early re-resection in patients with pT1 high-grade non-muscle invasive bladder cancer
Early re-resection facilitates accurate staging and clearance of residual disease and subsequent rates of tumour stage progression are significantly improved, and is advocated for all patients with HG-NMIBC. Expand


Effect of routine repeat transurethral resection for superficial bladder cancer: a long-term observational study.
Data suggest a favorable outcome regarding recurrence and progression in patients with superficial bladder cancer who undergo ReTURB, which is suggested at least in those at high risk when bladder preservation is intended. Expand
The value of a second transurethral resection in evaluating patients with bladder tumors.
  • H. Herr
  • Medicine
  • The Journal of urology
  • 1999
Routine repeat resection is advised to control noninvasive tumors and to detect residual tumor invasion. Expand
Is a second transurethral resection necessary for newly diagnosed pT1 bladder cancer?
Although second TUR dramatically changed the treatment strategy in a small percentage of cases, it is strongly recommend performing second T UR in all cases of primary pT1 disease, especially in high grade cases. Expand
Impact of a second transurethral resection on the staging of T1 bladder cancer.
Understaging for T1 disease is negligible after restaging TUR, and 13 percent of the patients who underwent immediate cystectomy after restaged TUR had a pathologic stage greater than pT1. Expand
Is repeated transurethral resection justified in patients with newly diagnosed superficial bladder cancer?
Patients with pT1 G3 tumors are at high risk of residual, or even invasive, cancer and should be offered definitive therapy as early as possible. Expand
Intravesical bacillus Calmette-Guerin versus mitomycin C for superficial bladder cancer: a formal meta-analysis of comparative studies on recurrence and toxicity.
PURPOSE We compare the therapeutic efficacy and toxicity of intravesical bacillus Calmette-Guerin (BCG) with mitomycin C on recurrence of stages Ta and T1 bladder carcinoma. MATERIALS AND METHODSExpand
Residual tumor discovered in routine second transurethral resection in patients with stage T1 transitional cell carcinoma of the bladder.
When a second transurethral resection was routinely performed in 46 patients for stage T1 bladder tumors residual disease was found in 20 despite the surgical report of complete resection, residual tumor was confirmed histologically in 10 of them. Expand
Guidelines on bladder cancer.
Recommendations are developed for diagnosis for bladder cancer in general, treatment of superficial and infiltrative bladder cancer, and follow-up after different types of treatment modalities, such as intravesical instillations, radical cystectomy, urinary diversions, radiotherapy and chemotherapy. Expand