The effect of renal insufficiency and hemodialysis on the pharmacokinetics of nalmefene.

@article{Matzke1996TheEO,
  title={The effect of renal insufficiency and hemodialysis on the pharmacokinetics of nalmefene.},
  author={Gary R. Matzke and R F Frye and Arthur C. Alexander and Robin Reynolds and Ruth Dixon and Jerrilyn Johnston and Raymond Rault},
  journal={Journal of clinical pharmacology},
  year={1996},
  volume={36 2},
  pages={144-51}
}
The disposition of nalmefene, an opioid antagonist intended for the reversal of opioid-induced respiratory depression, and its primary metabolite nalmefene glucuronide, were characterized in adult volunteers with normal renal function and in patients with end-stage renal disease (ESRD). The effect of hemodialysis on the elimination of nalmefene and nalmefene glucuronide also was assessed. Participants with normal renal function received a single intravenous dose of 2 mg, and patients with ESRD… CONTINUE READING