The effect of quercetin on neointima formation in a rat artery balloon injury model.

  title={The effect of quercetin on neointima formation in a rat artery balloon injury model.},
  author={Baosheng Huang and Wei Wang and Yu-cai Fu and Xiao-hui Zhou and Xin Wang},
  journal={Pathology, research and practice},
  volume={205 8},
Chronic administration of quercetin induces biomechanical and pharmacological remodeling in the rat coronary arteries.
It is found remodeling of the geometry of coronary arterioles to ensure higher dilatory reserve and nitrogen monoxide production, as well as lowered elastic stress of the vessel wall.
Role of IN-1233 in the prevention of neointimal hyperplasia after stent placement in a rat artery model.
Quercetin Ameliorates Diabetic Nephropathy by Reducing the Expressions of Transforming Growth Factor-β1 and Connective Tissue Growth Factor in Streptozotocin-Induced Diabetic Rats
It is suggested that quercetin improved renal function in rats with DN by inhibiting the overexpressions of TGF-β1 and CTGF in the kidney.
Quercetin Protects against Diabetes-Induced Exaggerated Vasoconstriction in Rats: Effect on Low Grade Inflammation
Quercetin is potential candidate to prevent diabetic vascular complications in both insulin deficiency and resistance via its inhibitory effect on inflammatory pathways especially NF-κB signaling.
Novel nanocomposite stent coating releasing resveratrol and quercetin reduces neointimal hyperplasia and promotes re-endothelialization.
Vasoprotection by melatonin and quercetin in rats treated with cisplatin.
It is demonstrated for the first time that melatonin and quercetin treatment may protect the aorta in cisplatin-based chemotherapy.
Quercetin Inhibits Pulmonary Arterial Endothelial Cell Transdifferentiation Possibly by Akt and Erk1/2 Pathways
Quercetin is demonstrated to be effective for pulmonary arterial hypertension (PAH) probably by inhibiting endothelial transdifferentiation possibly via modulating Akt and Erk1/2 expressions.
Arterial pharmacokinetics of red wine polyphenols: implications for novel endovascular therapies targeting restenosis.
Examining how drug polarity, drug load, and protein binding influence release from a polymer film and distribution within arterial tissue revealed that drugs associated with high- and low-protein-binding affinity result in markedly distinct arterial drug profiles, highlighting the importance of arterial partitioning and propagation of drug within arterIAL tissue in the rational design of DES coatings.
HPLC Method for Simultaneous Quantitative Detection of Quercetin and Curcuminoids in Traditional Chinese Medicines
The HPLC-UV method was found to be simple, accurate and precise and is recommended for routine quality control analysis of commercial Chinese medicine products containing the flour flavonoids as their principle components in the extracts.


Effect of quercetin on experimental hyperlipidemia and atherosclerosis in rabbits.
It was demonstrated that quercetin was effective in reducing serum triglycerides and cholesterol levels elevated by high-fat diet, after 12 weeks of the experiment and hypolipemic properties of the flavonoid were associated with the reduced formation of atherosclerotic plaques.
Intramuscular gene transfer of CGRP inhibits neointimal hyperplasia after balloon injury in the rat abdominal aorta.
It is demonstrated that CGRP potently inhibited neointimal thickening in the rat aorta, at least in part through its distinct effects on apoptosis and proliferation of VSMCs both in vivo and in vitro.
Thalidomide as a Potent Inhibitor of Neointimal Hyperplasia After Balloon Injury in Rat Carotid Artery
It is found that thalidomide, through its antiinflammatory and antiproliferative effects, significantly inhibits neointimal hyperplasia in balloon-injured rat carotid arteries.
The flavonoid quercetin inhibits dimethylnitrosamine‐induced liver damage in rats
It is suggested that quercetin may be useful in the preventing the development of hepatic fibrosis and in the in‐vivo hepatoprotective and anti‐fibrogenic effects against DMN‐induced liver injury.
Mechanisms of restenosis after coronary intervention: difference between plain old balloon angioplasty and stenting.
Long-Term Inhibition of Rho-Kinase Suppresses Neointimal Formation After Stent Implantation in Porcine Coronary Arteries: Involvement of Multiple Mechanisms
Results indicate that long-term inhibition of Rho-kinase suppresses in-stent neointimal formation by multiple mechanisms, including reduced vascular inflammation, enhanced apoptosis, and decreased collagen deposition.
Quercetin inhibits human vascular smooth muscle cell proliferation and migration.
Quercetin inhibits the proliferation and migration of AoSMC, concomitant with inhibition of mitogen-activated protein kinase phosphorylation, and provides new insights and a rationale for the potential use of quercet in the prophylaxis of cardiovascular diseases.
The flavonoid naringenin inhibits dimethylnitrosamine-induced liver damage in rats.
It is suggested that naringenin may be useful in preventing the development of hepatic fibrosis through in vivo hepatoprotective and anti-fibrogenic effects against DMN-induced liver injury.