The effect of pyrazines on the metabolism of tryptophan and nicotinamide adenine dinucleotide in the rat. Evidence of the formation of a potent inhibitor of aminocarboxy-muconate-semialdehyde decarboxylase from pyrazinamide.

@article{Nasu1981TheEO,
  title={The effect of pyrazines on the metabolism of tryptophan and nicotinamide adenine dinucleotide in the rat. Evidence of the formation of a potent inhibitor of aminocarboxy-muconate-semialdehyde decarboxylase from pyrazinamide.},
  author={S Nasu and K Yamaguchi and Shigeki Sakakibara and Hiroshi Imai and I Ueda},
  journal={Biochimica et biophysica acta},
  year={1981},
  volume={677 1},
  pages={
          109-19
        }
}
Effects of Dietary Pyrazinamide, an Antituberculosis Agent, on the Metabolism of Tryptophan to Niacin and of Tryptophan to Serotonin in Rats
TLDR
It is suggested from these results that the action of pyrazinamide against tuberculosis is linked to the increase in turnover of NAD and to the increased content of NAD in the host cells.
Growth-promoting Activity of Pyrazinoic Acid, a Putative Active Compound of Antituberculosis Drug Pyrazinamide, in Niacin-deficient Rats through the Inhibition of ACMSD Activity
TLDR
Results suggest that a derivative of POA metabolized by rats inhibited the ACMSD activity, the rate-limiting enzyme in the tryptophan-niacin pathway.
Effects of dietary pyrazinamide, tryptophan, or nicotinic acid and gamma-ray irradiation on levels of NAD and NADP in various organs of mice.
TLDR
By gamma-irradiation, NAD contents of thymus and spleen of all groups tended to be decreased, but those of kidney and liver were not always reduced, but in the latter two organs, significant NAD reduction was shown only in kidney ofPT-group and in liver of PT- and NA-groups.
Effects of Dietary Pyrazinamide , of Tryptophan to Niaein and ofan Antituberculosis Agent , on the Metabolism Tryptophan to Serotonin in Rats
and beyond, especially quinolinic acid, nicotinamide, IV`-methy]nicotinamide, and Ni-methyl-4-pyridone3-carboxamide, and therefore significantly increased the conversion ratio of tryptophan to niacin
Identification and expression of alpha cDNA encoding human 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (ACMSD): a key enzyme for the tryptophan-niacine pathway and quinolinate hypothesis.
TLDR
Brain ACMSD messages was down- and up-regulated in response to low protein diet and streptozocin-induced diabetes, respectively, suggesting that a pathway does exist by which the levels of quinolinate in the brain are regulated.
Mechanism of increases in L-kynurenine and quinolinic acid in renal insufficiency.
TLDR
Systemic administrations of pyrazinamide (ACMSDase inhibitor) increased serum Quin concentrations in control rats, demonstrating that changes in body AC MSDase activities in response to renal insufficiency are important factors for the determination of serum Quin concentration.
Peroxisome-proliferator regulates key enzymes of the tryptophan-NAD+ pathway.
TLDR
Data suggested that regulation of the key enzymes in the Trp-NAD+ pathway was associated with PPAR-alpha directly or indirectly, and as a consequence the hepatic NAD+ was increased by PPs.
Effects of peroxisome-proliferators on the TRP-NAD pathway.
TLDR
The results strongly suggest that the hepatic NAD increase might be caused by transcription of genes coding the key enzymes of the Trp-NAD pathway via PPAR.
...
1
2
...

References

SHOWING 1-10 OF 12 REFERENCES
Tryptophan pyrrolase of liver. II. The activating reactions in crude preparations from rat liver.
  • M. Piras, W. Knox
  • Chemistry, Biology
    The Journal of biological chemistry
  • 1967
Abstract The activation of the apoenzyme of tryptophan pyrrolase in preparations from hydrocortisone-induced rats was shown to consist of two separate, sequential steps, only the second of which is
Nicotinic acid treatment of hypercholesteremia. Comparison of plain and sustained-action preparations and report of two cases of jaundice.
TLDR
The most significant difference was the greater frequency and severity of side effects during treatment with the 3 sustained-action preparations, and this precluded the majority of patients from completing a 3-month period of treatment.
Template properties of liver chromatin.
Pharmacologic effects of nicotinic acid on human purine metabolism.
Hyperuricemia due to pyrazinamide.
...
1
2
...