The effect of pumpless extracorporeal CO2 removal on regional perfusion of the brain in experimental acute lung injury.

@article{Kreyer2013TheEO,
  title={The effect of pumpless extracorporeal CO2 removal on regional perfusion of the brain in experimental acute lung injury.},
  author={Stefan F X Kreyer and Thomas Muders and Henning Luepschen and Corinna Kricklies and Katharina Linden and Martin Soehle and Joerg Zinserling and Christian Putensen and Hermann Wrigge},
  journal={Journal of neurosurgical anesthesiology},
  year={2013},
  volume={25 3},
  pages={324-9}
}
BACKGROUND Lung-protective mechanical ventilation with low tidal volumes (V(T)) is often associated with hypercapnia (HC), which may be unacceptable in patients with brain injury. CO2 removal using a percutaneous extracorporeal lung assist (pECLA) enables normocapnia despite low V(T), but its effects on regional cerebral blood flow (rCBF) remain ambiguous. We hypothesized that reversal of HC by pECLA impairs rCBF in a porcine lung injury model. METHODS Lung injury was induced in 9… CONTINUE READING
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