The effect of proton pump inhibitors on the human microbiota.

  title={The effect of proton pump inhibitors on the human microbiota.},
  author={Benjamin J. Vesper and A Jawdi and Kenneth W Altman and G. Kenneth Haines and L. G. Tao and James A. Radosevich},
  journal={Current drug metabolism},
  volume={10 1},
Proton pump inhibitors (PPIs) are commonly used to treat acid-related diseases, most notably gastroesophageal reflux disease. PPIs are designed to shut down the gastric proton pump (H+/K+-ATPase) of parietal cells, thereby raising the pH of the stomach. While effective, a number of side effects have been associated with PPI use. Naturally occurring bacteria, some of which are acid-producing and contain ATPase enzymes, have also been found within the stomach, upper gastrointestinal tract, and… CONTINUE READING
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