The effect of protein binding on ivermectin uptake by bovine brain microvessel endothelial cells

@article{Audus1992TheEO,
  title={The effect of protein binding on ivermectin uptake by bovine brain microvessel endothelial cells},
  author={Kenneth L. Audus and S. R. Knaub and François L. Guillot and James M. Schaeffer},
  journal={Veterinary Research Communications},
  year={1992},
  volume={16},
  pages={365-377}
}
The effect of albumin binding on ivermectin uptake and transfer across the endothelial component of the blood-brain barrier (BBB) was determined with anin vitro model comprised of bovine brain microvessel endothelial cell (BMEC) monolayers. Cellular uptake of ivermectin was limited in the absence of albumin and 90% inhibited in the presence of 10% albumin… CONTINUE READING