The effect of proteasome inhibition on the generation of the human leukocyte antigen (HLA) peptidome.

Abstract

The Major histocompatibility complex (MHC) class I peptidome is thought to be generated mostly through proteasomal degradation of cellular proteins, a notion that is based on the alterations in presentation of selected peptides following proteasome inhibition. We evaluated the effects of proteasome inhibitors, epoxomicin and bortezomib, on human cultured… (More)
DOI: 10.1074/mcp.M112.026013

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