The effect of prostaglandins on the multiplication and cell-to-cell spread of herpes simplex virus type 2 in vitro.

@article{Baker1982TheEO,
  title={The effect of prostaglandins on the multiplication and cell-to-cell spread of herpes simplex virus type 2 in vitro.},
  author={D. Baker and J. Thomas and J. Epstein and D. Possilico and M. L. Stone},
  journal={American journal of obstetrics and gynecology},
  year={1982},
  volume={144 3},
  pages={
          346-9
        }
}
Herpes simplex virus type 2 (HSV-2) after infecting an individual has the ability to remain latent in nervous tissues. The factors that control herpesvirus infection, latency, and reactivation are poorly understood. Fever, menstruation, emotional stress, exposure to sunlight, and surgical resection have been associated with activation of latent herpes. The situations which activate latent herpes are associated with a local or systemic rise in prostaglandins. The data presented show that… Expand
The effect of indometacin, prostaglandin E2 and interferon on the multiplication of herpes simplex virus type 1 in human lymphoid cells
TLDR
The present observations together with previously published data would indicate that the inhibitory effect of IND on HSV-1 replication is independent of cell type or origin, while the enhancing effect of PGE2 on virus growth may depend on these factors. Expand
The effect of prostaglandin E2 on the initial immune response to herpes simplex virus infection.
TLDR
The data suggest a statistically significant suppression in nonspecific T cell mitogen stimulation (concanavalin A), as well as specific herpes simplex virus 1 and 2 stimulations as measured by tritiated thymidine uptake by lymphocytes when stimulated in the presence of prostaglandin E2. Expand
Antiherpetic action of prostaglandin D2.
TLDR
It is suggested that PGD2 has an antiherpetic activity in vitro and in vivo and reduced the mortality of the mice infected with HSV. Expand
Effects of dimethyl prostaglandin A1 on herpes simplex virus and human immunodeficiency virus replication.
TLDR
DmPGA1 has an unusual broad-spectrum antiviral activity against both HSV and HIV-1 in vitro and offers a new class of potential therapeutic agents for in vivo use. Expand
Effect of indomethacin on ultraviolet radiation-induced recurrent herpes simplex virus disease in guinea-pigs.
TLDR
The data suggest that indomethacin may modify u.v. radiation-induced recurrent lesions by decreasing viral reactivation when given before u. v. radiation exposure or by reducing prostaglandin-induced immunosuppression whengiven before or after exposure. Expand
Stress-associated immunomodulation and herpes simplex virus infections.
TLDR
It is suggested that the release of immunomodulating signal molecules due to stress can compromise the host's cellular immune response and trigger herpes simplex viral reactivation. Expand
Peripheral adrenergic stimulation and indomethacin in experimental ocular shedding of HSV.
TLDR
The beta adrenergic blocker, Timolol, reduced virus shedding when applied immediately before the epinephrine, but continued administration resulted in increased viral shedding, which suggests that latent virus may be depleted by repeated reactivations. Expand
The effect of modulating the synthesis of arachidonic acid cascade products on HSV lesion recurrence.
TLDR
It was found that topical steroids gave the greatest initial decrease in lesion number, while meclofenamate resulted in the greatest reduction of lesions by day 5 PRI, and chlorpromazine acted roughly equivalent to the steroid treated group by day 3 post recurrence induction (PRI). Expand
Inhibition of virus protein glycosylation as the mechanism of the antiviral action of prostaglandin A in Sendai virus-infected cells.
TLDR
SDS-PAGE analysis of [35S]methionine-labelled proteins showed that while the non-glycosylated viral polypeptides (P, NP and M) were normally synthesized in PGA1-treated cells, the viral glycoproteins HN and F0 were not detected. Expand
Inhibition of Cyclooxygenase Activity Reduces Rotavirus Infection at a Postbinding Step
TLDR
It is concluded that COXs and PGE2 are important mediators of rotavirus infection at a postbinding step and the ERK1/2 pathway mediated by PKA is involved in COX induction by rotav virus infection. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 13 REFERENCES
Prostanglandins enhance spread of herpes simplex virus in cell cultures.
TLDR
Analysis of the results suggest that prostaglandins can enhance cell-to-cell spread of HSV, but that cyclic AMP is probably not involved in this effect. Expand
Reactivation of herpes simplex virus infection by ultraviolet light and possible involvement of prostaglandins.
TLDR
Immunosuppressive drugs failed to induce clinical signs of reactivation but irradiation of the skin of the originally infected ear with ultraviolet light or injection of prostaglandin E2 or PBSA into this site, caused reactivation of infection. Expand
AN ALTERNATIVE THEORY OF HERPES-SIMPLEX RECURRENCE AND A POSSIBLE ROLE FOR PROSTAGLANDINS
Reactivation of herpes-simplex is thought to require stimulation of latent virus in the sensory ganglion before the virus travels to the skin and causes a lesion. An alternative theory is proposedExpand
Effect of prostaglandins and cyclic adenosine 3',5'-monophosphate modulators on herpes simplex virus growth and interferon response in human cells
TLDR
The hypothesis that prostaglandin elaboration in vivo could contribute to exacerbations of HSV infections by compromising the host's interferon defense system is supported. Expand
Activation of latent herpes simplex by trigeminal sensory-root section.
TLDR
The frequently made clinical observation that trigeminal sensory-root section for trigemINAL neuralgia is often followed by facial herpes prompted the study of this phenomenon in some patients. Expand
Acute and recurrent infection with herpes simplex virus in the mouse: a model for studying latency and recurrent disease.
TLDR
The system of ear infection in the mouse is presented as a new model for studying neurovirulence, and latent and recurrent infection with herpes simplex virus. Expand
Prostaglandins and the immune response.
TLDR
No definitive evidence exists that compounds other than the classical Pgs are active in immune cell inhibition, but the recent indications that Pgs may mediate their effects through the cyclic endoperoxides and non-prostanoate metabolites may prove to be an important challenge to the many proposed roles of Pgs. Expand
Herpesvirus hominis Infection in Patients with Myeloproliferative and Lymphoproliferative Disorders
TLDR
Infection with Herpesvirus hominis was found to be more frequent in patients with myeloproliferative and lymphoprolifier disorders than in normal populations or patients with other diseases, suggesting a possible impairment of cell-mediated immunity. Expand
Herpes simplex infections in hematologic malignancies.
TLDR
It is shown that patients with hematologic malignancies are especially vulnerable to the development of HSV infections affecting the skin and mucous membranes. Expand
Recovery of herpes-simplex virus from human trigeminal ganglions.
Abstract In six of seven patients, herpes-simplex virus was recovered from trigeminal ganglions obtained at autopsy from unselected cadavers less than 12 hours after death and maintained in culture...
...
1
2
...