The effect of prostaglandins and thromboxane A2 on coronary vessel tone--mechanisms of action and therapeutic implications.

@article{Schroer1993TheEO,
  title={The effect of prostaglandins and thromboxane A2 on coronary vessel tone--mechanisms of action and therapeutic implications.},
  author={Karsten Schroer},
  journal={European heart journal},
  year={1993},
  volume={14 Suppl I},
  pages={34-41}
}
Prostaglandins (PGI2, PGE2, PGF2 alpha) and thromboxane (TX) A2 are vasoactive, cell membrane-derived lipid mediators that are formed in response to stimulation of vascular smooth muscle cells by a variety of chemical agonists. Different receptor subtypes mediate the contractile and relaxing effects of prostaglandins and TXA2 on coronary vascular smooth muscle: a high-affinity (kD: > or = 1 nM) PGH2/TXA2 receptor mediates the contractile actions of TXA2; a low-affinity (kD 100-200 nM) receptor… CONTINUE READING
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