The effect of propofol on oxidative stress in platelets from surgical patients.

  title={The effect of propofol on oxidative stress in platelets from surgical patients.},
  author={Jos{\'e} Pedro De La Cruz and Alba Zanca and Jos{\'e} Antonio Carmona and Felipe S{\'a}nchez de la Cuesta},
  journal={Anesthesia and analgesia},
  volume={89 4},
UNLABELLED We investigated the changes in oxidative stress in platelets from surgical patients anesthetized with propofol. We studied 60 surgical patients (ASA physical status I and II) and 12 healthy volunteers. The patients were divided into three groups: anesthesia induced with an IV bolus dose of 4 mg/kg thiopental; anesthesia induced with an IV bolus dose of 2 mg/kg propofol; and total IV anesthesia (induction with propofol 2 mg/kg, infusion with propofol 10 mg/kg during the first 10 min… 

Effect of propofol on oxidative stress status in erythrocytes from dogs under general anaesthesia

The results of this study showed that an infusion dose of propofol has antioxidant effects in dogs, which may be beneficial to patients in whom free radicals play a role in oxidative stress, such as those with ischemia.

The Effect of Propofol on the Interaction of Platelets with Leukocytes and Erythrocytes in Surgical Patients

Propofol inhibited platelet aggregation in surgical patients mainly as a result of the inhibition of Tx synthesis and the increase in nitric oxide production.

Effects of propofol on the leukocyte nitric oxide pathway: in vitro and ex vivo studies in surgical patients

It is concluded that propofol stimulated constitutive NO production and inhibited inducible NO production, possibly by curtailing the stimulation of iNOS by inflammatory mediators in surgical patients.

Evaluation of anti-oxidative effects of propofol in experimental diabetes

The results of this study demonstrate ameliorative effects of propofol on oxidative status in an alloxan-induced model of diabetes in mice.

Effects of Propofol on Endotoxin-Induced Acute Lung Injury in Rabbit

Propofol attenuated endotoxin-induced acute lung injury in rabbits mainly by inhibiting neutrophil and IL-8 responses, which may play a central role in sepsis-related lung injury.

Ketamine or propofol anesthesia in dogs: how do they affect cytokines, antioxidants and neutrophil functions?

The administration of ketamine was found to have a positive effect both on the antioxidant system and the neutrophil and positive and negative effects of propofol on different parts of the immune system were observed.

Effect of Propofol, Sevoflurane and Desflurane on Systemic Redox Balance

Propofol showed antioxidant properties, while Sevoflurane and Desflurane seemed to shift the redox balance towards oxidation, yet without inducing overt oxidative damage.

Oxidative Stress Status During Exposure to Propofol, Sevoflurane and Desflurane

In this mechanically ventilated swine model, desflurane seemed to induce a local and systemic oxidative stress, whereas propofol and sevoflurane were more likely to have antioxidant properties.

Propofol Attenuates Toxic Oxidative Stress by CCl4 in Liver Mitochondria and Blood in Rat

Oxidative stress induced with CCl4 in liver mitochondria was evident by a significant increase in enzymatic activities of GPx, SOD, and LPO and decreased of GSH and vailability of mitochondria.

Evaluation of DNA damage and lipoperoxidation of propofol in patients undergoing elective surgery

Propofol does not induce DNA damage in WBCs and does not alter MDA in plasma of patients, as evaluated in patients undergoing propofol anaesthesia.



Increase in antioxidant capacity of plasma during propofol anesthesia.

It is concluded that the capacity of plasma to inhibit lipid peroxidation increases in patients during TIVA maintained with a continuous propofol infusion.

The In Vitro Effects of Propofol on Tissular Oxidative Stress in the Rat

It is concluded that propofol not only inhibits lipid peroxidation, but also enhances the cellular antioxidant defense system, and is thus able to prepare tissues against oxidative attack by boosting stores of reduced glutathione.

Antioxidant activity of propofol in blood from anaesthetized patients.

Despite there being no overall increase in plasma antioxidant activity, the lipid soluble component of blood antioxidant activity appears to be increased by propofol.

Inhibition of lipid peroxidation in isolated rat liver mitochondria by the general anaesthetic propofol.

[The lipid peroxidation level and antioxidant status of the plasma in patients operated on under propofol (Diprivan) anesthesia].

The antioxidant capacity of blood plasma was decreased weakly 24 hours after anaesthesia, in comparison of the levels registered before anaesthesia and the good correlation between fluorescent products and antioxidant status of plasma was observed.

Propofol Inhibits In Vitro Platelet Aggregation in Human Whole Blood

It is concluded that propofol reduces the platelet activity in human whole blood in vitro in a concentration-dependent and antiaggregant effect.

Effect of propofol on in vitro lipid peroxidation induced by different free radical generating systems: a comparison with vitamin E.

The study suggests that propofol could be beneficial as an anesthetic or sedative drug in patients presenting pathologies associated with free radical reactions.

Platelet activation and lipid peroxidation in patients with acute ischemic stroke.

Platelet activation occurs repeatedly in a cyclooxygenase-dependent fashion during the first few days after an acute ischemic stroke, and increased thromboxane production was independently associated with severity of stroke on admission, atrial fibrillation, and treatment with cyclo oxygenase-inhibiting drugs.

The widely used anesthetic agent propofol can replace alpha-tocopherol as an antioxidant.

It is suggested that propofol acts similarly to alpha-tocopherol as a chain breaking antioxidant in liver microsomal membranes.

The antioxidant potential of propofol (2,6-diisopropylphenol).

It is concluded that the free radical scavenging properties of 2,6-diisopropylphenol resemble those of the endogenous antioxidant alpha-tocopherol (vitamin E).