The effect of prolonged simvastatin application on serotonin uptake, membrane microviscosity and behavioral changes in the animal model.

@article{Vevera2016TheEO,
  title={The effect of prolonged simvastatin application on serotonin uptake, membrane microviscosity and behavioral changes in the animal model.},
  author={Jan Vevera and Karel Vale{\vs} and Zdeněk Fi{\vs}ar and Jana Hroudov{\'a} and Namrata Singh and Ale{\vs} Stuchl{\'i}k and Petr Kacer and Tereza Nekov{\'a}řov{\'a}},
  journal={Physiology & behavior},
  year={2016},
  volume={158},
  pages={112-20}
}
Simvastatin and other statins (HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase inhibitors) are extensively used in clinical practices and are very effective in decreasing serum low-density lipoprotein cholesterol. However, their effect on cholesterol synthesis in central nervous system and its behavioral consequences have not been fully understood yet. We have studied selected biologic traits potentially affected by statin treatment - serotonin (5-HT) uptake in platelets, membrane… CONTINUE READING
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