The effect of progestins on submaxillary gland epidermal growth factor: demonstration of androgenic, synandrogenic and antiandrogenic actions.

  title={The effect of progestins on submaxillary gland epidermal growth factor: demonstration of androgenic, synandrogenic and antiandrogenic actions.},
  author={L. Bullock and P. Barthe and I. Mowszowicz and D. Orth and C. Bardin},
  volume={97 1},
The effects of progestins (0.1, 1.0, 6-10 mg/day) alone and in combination with testosterone (0.1 mg/day) on immunoreactive epidermal growth factor (EGF) concentrations in submaxillary glands from normal and androgen-insensitive (tfm/y) mice were studied. Since androgens are known to stimulate increased EGF levels, the responses to progestins were interpreted as androgenic, synandrogenic or antiandrogenic if they simulated, potentiated or inhibited androgen response, respectively. Of the… Expand
Androgenic, antiandrogenic, and synandrogenic actions of progestins: role of steric and allosteric interactions with androgen receptors.
Data imply the involvement of the androgen receptor in the nuclear retetion of [3H]MPA, a progestin with both androgenic and synandrogenic activities that stimulated the growth of mouse prostate-seminal vesicle, kidney, and submaxillary gland in vivo. Expand
Effect of medroxyprogesterone acetate (MPA) and serum factors on cell proliferation in primary cultures of an MPA-induced mammary adenocarcinoma
It is concluded that MPA stimulates cell growth of primary cultures of MPA-induced PD tumors via PR, providing support for a direct effect of M PA which may be mediated or potentiated by serum factors. Expand
The biological actions and metabolism of 6 alpha-methylprogesterone: a progestin that mimics and modifies the effects of testosterone.
6MP modifies the action of T on renal β-glucuronidase in C57BL/6J mice (with the Gus-rb allele) in a manner that is quite diffrent from its previously reported effect on BALB/cJ mice. Expand
Progestins can mimic, inhibit and potentiate the actions of androgens.
There is an extensive background on the androgen responsiveness of the mouse kidney which can be demonstrated histologically by hypertrophy of the Bowman's capsule and the proximal convoluted tubule and it is not certain at this time whether a similar mechanism is involved in the potentiation of androgen action on other organs such as the prostate. Expand
In vitro and in vivo binding of progestins to the androgen receptor of mouse kidney: correlation with biological activities.
MPA, the most biologically potent androgenic progestin, bound to the cytoplasmic androgen receptor with less affinity than 6MP or the antiandrogenicprogesterone CPA. Expand
Progestagens androgenic action on the bone of male castrated mice.
The results indicate that only NETA at the dose used in hormonal therapy for prevention of osteoporosis has a slight protective effect against bone mineral loss in castrated mice. Expand
Effects of female hormones and 3,5,3'-triiodothyronine or dexamethasone on induction of epidermal growth factor and proteinases F, D, A, and P in the submandibular glands of hypophysectomized male mice.
Results show that Pro by itself is as capable as androgens, thyroid hormone, or glucocorticoid in regulating expression of these submandibular polypeptides, and that its action can be modulated by other pituitary-dependent hormones. Expand
The additive effects of progestins on testosterone-stimulated hepatic ethylmorphine metabolism and cytochrome P-450 content
It is concluded that the mechanism of action of progestins on the liver differs from that on other tissues such as kidney and sub-maxillary gland where progestin potentiate and inhibit androgen action. Expand
The effects of testosterone and progestins on the rate of beta-glucuronidase synthesis in mouse kidney as studied with an immunoprecipitation assay.
Whether progestins, like androgens, exert their effects on β-glucuronidase activity by changing its rate of synthesis is determined. Expand
The Role of Receptors in the Anabolic Action of Androgens
This chapter presents studies that suggest that androgens elicit their initial action in mouse kidney nuclei by preferentially stimulating the fractional activity of RNA polymerase II. Expand