The effect of pro-inflammatory cytokines on immunophenotype, differentiation capacity and immunomodulatory functions of human mesenchymal stem cells.

@article{Pourgholaminejad2016TheEO,
  title={The effect of pro-inflammatory cytokines on immunophenotype, differentiation capacity and immunomodulatory functions of human mesenchymal stem cells.},
  author={Arash Pourgholaminejad and Nasser Aghdami and Hossein Baharvand and Seyed Mohammad Moazzeni},
  journal={Cytokine},
  year={2016},
  volume={85},
  pages={
          51-60
        }
}
  • Arash Pourgholaminejad, Nasser Aghdami, +1 author Seyed Mohammad Moazzeni
  • Published in Cytokine 2016
  • Biology, Medicine
  • Mesenchymal stem cells (MSCs), as cells with potential clinical utilities, have demonstrated preferential incorporation into inflammation sites. Immunophenotype and immunomodulatory functions of MSCs could alter by inflamed-microenvironments due to the local pro-inflammatory cytokine milieu. A major cellular mediator with specific function in promoting inflammation and pathogenicity of autoimmunity are IL-17-producing T helper 17 (Th17) cells that polarize in inflamed sites in the presence of… CONTINUE READING

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