The effect of prenatal exposure to the phytoestrogen genistein on sexual differentiation in rats.

@article{Levy1995TheEO,
  title={The effect of prenatal exposure to the phytoestrogen genistein on sexual differentiation in rats.},
  author={James R Levy and Kenneth A. Faber and L Ayyash and Claude L. Hughes},
  journal={Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine},
  year={1995},
  volume={208 1},
  pages={60-6}
}
Exposure to naturally occurring estrogens during critical periods of development can alter morphologic and physiologic markers of sexual differentiation. The current experiment characterizes the effects of in utero treatment with genistein, an isoflavonoid phytoestrogen, on birth weight, anogenital distance (AGD) at birth. GnRH stimulated luteinizing hormone (LH) secretion, volume of the sexually dimorphic nucleus in the preoptic area of the hypothalamus (SDN-POA), puberty onset, and vaginal… CONTINUE READING
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