The effect of preincubation with cimetidine on the N-hydroxylation of dapsone by human liver microsomes.

@article{Tingle1991TheEO,
  title={The effect of preincubation with cimetidine on the N-hydroxylation of dapsone by human liver microsomes.},
  author={Malcolm Drummond Tingle and Michael D Coleman and Brian Kevin Park},
  journal={British journal of clinical pharmacology},
  year={1991},
  volume={32 1},
  pages={120-3}
}
We have examined the ability of cimetidine to inhibit the oxidative metabolism and hence haemotoxicity of dapsone in vitro, using a two compartment system in which two Teflon chambers are separated by a semi-permeable membrane. Compartment A contained a drug metabolizing system (microsomes prepared from human or rat liver +/- NADPH), whilst compartment B… CONTINUE READING