The effect of pravastatin and atorvastatin on coenzyme Q10.

@article{Bleske2001TheEO,
  title={The effect of pravastatin and atorvastatin on coenzyme Q10.},
  author={Barry E Bleske and Rupert A. Willis and Mary Anthony and N Casselberry and M Datwani and Virginia E Uhley and S G Secontine and Michael J. Shea},
  journal={American heart journal},
  year={2001},
  volume={142 2},
  pages={E2}
}
BACKGROUND Coenzyme Q10 (CoQ10) is an antioxidant and plays an important role in the synthesis of adenosine triphosphate. Studies suggest that 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors reduce CoQ10 levels; however, no studies have directly compared HMG-CoA reductase inhibitors in a randomized crossover fashion. METHODS Twelve healthy volunteers received either 20 mg pravastatin (P) or 10 mg atorvastatin (A) for 4 weeks in a randomized crossover fashion. There was a… CONTINUE READING