The effect of powder type, free moisture and deformation behaviour of granules on the kinetics of fluid-bed granulation.

@article{Abberger2001TheEO,
  title={The effect of powder type, free moisture and deformation behaviour of granules on the kinetics of fluid-bed granulation.},
  author={Thomas Abberger},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2001},
  volume={52 3},
  pages={327-36}
}
The effects of two types of powder, lactose and corn starch, and of free moisture on the kinetics of fluid-bed granulation have been investigated using population balance modelling. A coalescence kernel that considered the deformation behaviour of the granules was used. The best fit of the experimental data was obtained for both materials by assuming that the granules underwent plastic deformation. The predicted cumulative number fractions were in very good agreement with the experimental data… CONTINUE READING

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