The effect of plant phenols on the expression and activity of phorbol ester-induced PKC in mouse epidermis.

@article{Szaefer2007TheEO,
  title={The effect of plant phenols on the expression and activity of phorbol ester-induced PKC in mouse epidermis.},
  author={Hanna M. Szaefer and Jolanta Kaczmarek and Maria Rybczyńska and Wanda Baer-Dubowska},
  journal={Toxicology},
  year={2007},
  volume={230 1},
  pages={1-10}
}
Protein kinase C (PKC) is thought to be a major intracellular receptor for the mouse skin tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). The diversity of PKC isoforms, and their central role in many signaling pathways, makes them important targets for potential chemopreventive agents. Our earlier studies showed that the plant phenols protocatechuic acid, chlorogenic acid and tannic acid alter the activity of enzymes involved in carcinogen activation, inhibit the formation of… CONTINUE READING