The effect of pituitary adenylate cyclase activating polypeptide on cultured rat cardiocytes as a cardioprotective factor

@article{Sano2002TheEO,
  title={The effect of pituitary adenylate cyclase activating polypeptide on cultured rat cardiocytes as a cardioprotective factor},
  author={Hirofumi Sano and Atsuro Miyata and Takeshi Horio and Toshio Nishikimi and Kenji Kangawa},
  journal={Regulatory Peptides},
  year={2002},
  volume={109},
  pages={107-113}
}
In the cardiovascular system, pituitary adenylate cyclase activating polypeptide (PACAP) exhibits not only vasodilation but also positive inotropic action by increasing cardiac output. Then the effect of PACAP in cultured cardiovascular cells was examined. In neonatal rat myocytes, PACAP evoked concentration-dependent increase in intracellular cyclic AMP content more potently than vasoactive intestinal polypeptide (VIP). However, in neonatal rat nonmyocytes, PACAP and VIP showed equal potency… CONTINUE READING

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