The effect of physiological levels of glucagon-like peptide-1 on appetite, gastric emptying, energy and substrate metabolism in obesity

@article{Flint2001TheEO,
  title={The effect of physiological levels of glucagon-like peptide-1 on appetite, gastric emptying, energy and substrate metabolism in obesity},
  author={Anne Flint and Anne Raben and AK Ersb\oll and J Juul Holst and A. -S. Astrup},
  journal={International Journal of Obesity},
  year={2001},
  volume={25},
  pages={781-792}
}
OBJECTIVE: Peripheral infusions of glucagon-like peptide-1 (GLP-1) in humans have been shown to inhibit gastrointestinal motility and decrease hunger and energy intake. However, these investigations used supraphysiological doses. The objective of this study was to investigate the effects of a GLP-1 infusion in a physiological dose on appetite sensations, energy intake, gastric emptying, energy and substrate metabolism.METHODS: Eighteen obese men participated in the placebo-controlled… CONTINUE READING