The effect of photodynamic therapy on the microcirculation.

  title={The effect of photodynamic therapy on the microcirculation.},
  author={Malcolm W. R. Reed and Frederick N. Miller and Thomas Jeffery Wieman and Michael T. Tseng and Constanze Pietsch},
  journal={The Journal of surgical research},
  volume={45 5},
Photodynamic therapy (PDT) is a new form of cancer therapy involving tumor localization by photosensitizing drugs such as dihematoporphyrin ether (DHE). Light irradiation of drug-sensitized tissue results in photoactivation of DHE and tumor necrosis. The mechanism of action is incompletely understood but involves the generation of singlet oxygen which produces cytotoxic effects on tissues containing the compound. In addition, microcirculatory aberrations have been described during PDT. We have… CONTINUE READING
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