The effect of phosphodiesterase inhibition on gallbladder motility in vitro.

@article{Lindaman2002TheEO,
  title={The effect of phosphodiesterase inhibition on gallbladder motility in vitro.},
  author={Brian A Lindaman and Marilyn M. Hinkhouse and Jeffrey L. Conklin and Joseph J. Cullen},
  journal={The Journal of surgical research},
  year={2002},
  volume={105 2},
  pages={102-8}
}
BACKGROUND Coffee consumption decreases the risk of gallstone disease. The proposed motility effects of caffeine, a phosphodiesterase (PDE) inhibitor, are unknown. The aim of our study was to determine the effect of caffeine and specific PDE inhibitors on gallbladder motility in vitro. METHODS Gallbladder muscle strips from opossums were attached to force transducers. Baseline tone, electrical field stimulation (EFS)-induced nitric oxide-mediated off responses, and changes in the… CONTINUE READING

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