The effect of phosphate accumulation on metal ion homeostasis in Saccharomyces cerevisiae

@article{Rosenfeld2010TheEO,
  title={The effect of phosphate accumulation on metal ion homeostasis in Saccharomyces cerevisiae},
  author={Leah Rosenfeld and Amit R Reddi and Edison Leung and Kimberly Aranda and Laran T. Jensen and Valeria C Culotta},
  journal={JBIC Journal of Biological Inorganic Chemistry},
  year={2010},
  volume={15},
  pages={1051-1062}
}
Much of what is currently understood about the cell biology of metals involves their interactions with proteins. By comparison, little is known about interactions of metals with intracellular inorganic compounds such as phosphate. Here we examined the role of phosphate in metal metabolism in vivo by genetically perturbing the phosphate content of Saccharomyces cerevisiae cells. Yeast pho80 mutants cannot sense phosphate and have lost control of phosphate uptake, storage, and metabolism. We… CONTINUE READING

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Gurthie C, Fink GR (eds) Methods in enzymology

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