The effect of phenytoin medication on dentin apposition, root length, and caries progression in rat molars.

@article{Larmas1992TheEO,
  title={The effect of phenytoin medication on dentin apposition, root length, and caries progression in rat molars.},
  author={Markku Larmas and Leo Tj{\"a}derhane},
  journal={Acta odontologica Scandinavica},
  year={1992},
  volume={50 6},
  pages={345-50}
}
To determine the effect of phenytoin (PHT) on dentin apposition and the rate of caries progression in dentin, 40 Wistar rats were treated daily for 35 days with intraperitoneal injections of 5,5-diphenylhydantoin. Twenty-eight controls received saline with pH adjusted to that of PHT. One PHT and one control group were fed a 43% sucrose diet, and the others a non-cariogenic pellet diet. Streptococcus sobrinus was inoculated to induce caries. Schiff staining was used to determine caries. The… CONTINUE READING

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