The effect of perindopril and hydrochlorothiazide alone and in combination on blood pressure and on the renin-angiotensin system in hypertensive subjects

@article{Brown1990TheEO,
  title={The effect of perindopril and hydrochlorothiazide alone and in combination on blood pressure and on the renin-angiotensin system in hypertensive subjects},
  author={Christa L Brown and C. I. Backhouse and J. C. Grippat and J. Ph. Santoni},
  journal={European Journal of Clinical Pharmacology},
  year={1990},
  volume={39},
  pages={327-332}
}
The pharmacodynamic effects and acceptability of perindopril (4 mg daily) and hydrochlorothiazide (25 mg daily) given alone or in combination for 1 month were investigated in a double-blind, placebo controlled, parallel group study. The pharmacokinetics of perindopril and its active metabolite perindoprilat and the time course of angiotensin converting enzyme inhibition were studied for 72 h following the last dose of treatment in the two appropriate groups. Similar decreases in blood pressure… CONTINUE READING

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