The effect of perhexiline on myocardial protection during coronary artery surgery: a two-centre, randomized, double-blind, placebo-controlled trial

@inproceedings{Drury2013TheEO,
  title={The effect of perhexiline on myocardial protection during coronary artery surgery: a two-centre, randomized, double-blind, placebo-controlled trial},
  author={Nigel E Drury and Neil John Howell and Melanie Calvert and Ralf J. M. Weber and Eshan Lankapura Senanayake and Michael E. Lewis and Jonathan A. J. Hyde and David H. Green and Jorge G. Mascaro and Timothy Royce Graham and Stephen J. Rooney and Mark R. Viant and Nick Freemantle and Michael P. Frenneaux and Domenico Pagano and L. Keoki Williams and Aaron Matthew Ranasinghe and David Hauton and Robert Cramb and Uday P Dandekar and Andrew S. Cohen and Robert S Kong and Sue I. Brown and Emma H. Gardner and Ailie MacKenzie},
  booktitle={European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery},
  year={2013}
}
OBJECTIVES Perhexiline is thought to modulate metabolism by inhibiting mitochondrial carnitine palmitoyltransferase-1, reducing fatty acid uptake and increasing carbohydrate utilization. This study assessed whether preoperative perhexiline improves markers of myocardial protection in patients undergoing coronary artery bypass graft surgery and analysed its effect on the myocardial metabolome. METHODS In a prospective, randomized, double-blind, placebo-controlled trial, patients at two centres… CONTINUE READING
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