The effect of particle size on the genotoxicity of gold nanoparticles.

  title={The effect of particle size on the genotoxicity of gold nanoparticles.},
  author={Qiyue Xia and Hongxia Li and Ying Liu and Shuyang Zhang and Qiyi Feng and Kai Xiao},
  journal={Journal of biomedical materials research. Part A},
  volume={105 3},
Despite the increasing biomedical applications of gold nanoparticles (AuNPs), their toxicological effects need to be thoroughly understood. In the present study, the genotoxic potential of commercially available AuNPs with varying size (5, 20, and 50 nm) were assessed using a battery of in vitro and in vivo genotoxicity assays. In the comet assay, 20 and 50 nm AuNPs did not induce obvious DNA damage in HepG2 cells at the tested concentrations, whereas 5 nm NPs induced a dose-dependent increment… CONTINUE READING
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